First created by Glaxo Smith Kline and Ligand Pharmaceuticals in 1992, GW-501516 (Cardarine) is a SARMS that binds to the Peroxisome proliferator-activated receptor (PPARs). Cardarine, when binding to the PPAR receptor, recruits the coactivator PGC-1a (a transcriptional coactivator that is the central inducer of mitochondrial biogenesis in cells) enzyme. This stimulates an increase in the express of genes that are associated with energy expenditure.
Also known as Endurobol, Cardarine has the efficacy of activating AMP-activated protein kinase and stimulating the uptake of glucose in skeletal muscle tissue. GW is often combined with Insulin-like growth factor-LR3 to attain permanent lean muscle gains and a lean hard shredded look. A dosage of 10 mg every day for a period of 8 weeks is sufficient to stimulate significant endurance improvements.
One of the biggest benefits associated with GW-501516 (Cardarine) is that it shows great potential to melt off stubborn fat while still being non-catabolic. In other words, GW users can expect fat loss while holding on to muscle. Furthermore, Cardarine is known to increase good cholesterol levels (HDL levels) and decrease bad cholesterol levels (LDL levels). In addition to these unique advantages, the use of GW-501516 is also associated with improved cardiovascular health, prevention of diabetes, and enhanced nutrient partitioning ability of the body.
Cardarine is considered a wonder compound by many to take endurance and cardio output to unimaginably high levels. All these benefits make Cardarine the ideal drug for bodybuilders and athletes and even those involved in marathons, boxing, weight training, hiking, hockey, swimming, and cycling.
Commonly used as a cutting cycle drug, Cardarine allows holding onto hard-earned muscle on a calorie deficit diet. It is considered the best combination to Trenbolone. Trenbolone makes it extremely unviable to perform sufficient cardio activity without getting winded very easily. Using Cardarine with Trenbolone helps to keep endurance level at the top peak.
A big majority of athletes stack Cardarine 20mg per day and MK-2866 (Ostraine) 25mg per day for a period of 10-12 weeks to cut down, and follow it with post cycle therapy. For bulking purposes, Cardarine (20mg per day) is usually stacked with MK-677 25mg per day and LGD-4033 10mg per day in a cycle of 10-12 weeks, followed with post cycle therapy.
It is for these and many more reasons that Cardarine is rated by amateur and professional athletes and bodybuilders as the most effective boosting research chemical on the planet. GW is ideally used by men and women in cycles of 8-14 weeks in daily dosages of 10-20mg every day.
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